Setrakian leads Eph, Fet and Nora in the hunt for the Master’s lair. Left behind at the pawnshop with Mariela, Zack risks his safety for Mariela’s sake.

A secret autopsy demonstrates the bizarre progression of the mystery virus, prompting Jim to make a startling confession. Eph and Nora race to find the father of the youngest victim…

The four survivors begin manifesting strange symptoms, but Eph and Nora’s attempt to quarantine them is thwarted as the disinformation campaign begins. Meanwhile, in jail, Setrakian receives a surprise visit…

When a plane lands in New York City with everyone on board dead, Dr. Ephraim Goodweather, head of the CDC’s Canary Project, and his team are called upon to investigate….

Eph and Nora finally see their lethal virus in action. Fet takes the security of Red Hook into his own hands while Dutch and Setrakian set off for Staten Island…

Horatio delves into Delko’s past to find the killer who targets the motel Delko is staying at.

It’s time for changes at the ER when Anspaugh makes an unpopular decision. Abby has old demons to fight with, which distance her from friends and family. Even Luka seems…