After warning Kelly to leave the city with Zack ahead of the spreading plague, Eph is arrested by the FBI. Eichhorst has one final job for Gus, while Setrakian realizes…

The demon who cursed the Earp heir reveals himself in a shocking turn of events that will leave the team forever changed.

Dean goes off on his own to take on a case. Meanwhile, Castiel has an idea of how he can help Sam track down God.