Clark has second thoughts about Lana marrying Lex, and Lana has the same concerns. Meanwhile, the doctor involved in the secret behind Lana’s pregnancy threatens Lex with his knowledge.

Dean, Sam and Castiel deal with Cain’s return. Crowley and Rowena continue to grow closer but when Crowley bails on plans with his mother to help the Winchesters, Rowena lets…

The Winchesters must deal with a dangerous spirit bound to an old family portrait that brings misfortune and death to anyone who buys it.