Sully ends up badly beaten and partially paralyzed following a run in with buffalo hunters who were hired by the railroad to clear the buffalo and Indians out of the…

Dr. Mike takes in Red McCall, a down-and-out cowboy, and his ailing half-breed infant child. McCall reaches the end of his rope trying to care for his baby, so after…

Michaela “Mike” Quinn, of Boston, followed in her father’s footsteps by becoming a doctor. Dr. Mike worked side by side her father. But his sudden death caused her the loss…

Mike and Sully go to the Reverend for a dose of preventative pre-marital counseling, and recall the path of their romance.

Sully and the kids must help Mike deal with the emotional aftermath of the Washita massacre; Robert E and Grace must return to Cloud Dancing the Indian baby Mike and…

Mike and Sully arrive too late to avert Custer’s slaughter of the Indians at the Washita River; Brian befriends an Indian boy destined to die at Washita; Robert E &…

Sully takes a job as an Indian Agent, only to discover corruption’s rife within the system. Meanwhile, liquor arrives on the reservation, and Snow Bird miscarries due to malnutrition.

A troop of black cavalry soldiers ride into town intending to cover themselves in glory by eradicating hostile Dog Soldiers who’ve been attacking the railroad. Mike commits an act of…

Mike and Sully work to treat a typhus epidemic at Black Kettle’s camp, which begins after Mike and Sully unwittingly convince Black Kettle to accept government blankets infected with the…

Jake, Loren and Horace are out hunting when Jake, mistaking an Indian for a deer, accidentally shoots and kills him. During the melee, Horace is wounded by an arrow, which…