With all of Harlem bearing witness, Luke takes on the fight of his life in hopes of emerging as the defender his city needs.

Cottonmouth strikes back at Luke by taking his vengeance out on the people of Harlem, while detectives Knight and Scarfe face an unexpected threat.

Luke teams up with an unlikely ally to combat a new strain of heroin. As Shades plows ahead with his plan, a massive party draws everyone to the club.